Colon Cancer Risk Factors in Jiashan County of Zhe-jiang Province, the Highest Incidence Area in China

摘要

OBJECTIVE To investigate the risk factors of colon cancer in Jiashan county, the highest incidence area in China and to provide a scientific basis for monitoring and prevention. METHODS With a population-based case-control study, 109 colon cancer patients with 1:7 matched controls were interviewed with uniform questionnaires. Conditional logistic regression was used for univariate and multivari-ate analysis of colon cancer. RESULTS High monthly pork consumption (OR = 1.608), and high monthly animal fat consumption (OR=1.391) over a ten-year period, psychological depression (OR=9.887), negative emotion (OR = 1.723), lower digestive -tract diseases (OR=4.163), and history of colorectal cancer in first-degree relatives (OR=3.421) were the main risk factors of colon cancer. During that time, high monthly vegetable consumption was a protective factor for colon cancer (OR=0.422). CONCLUSIONS Colon cancer in Jiashan county was related to dietary factors. The research results support the colon cancer etiological hypothesis of" fat-bile acid" and "deficiency of dietary fibre". Psychological depression, inheritance and lower digestive tract diseases were also correlated with colon cancer.