Synthesis, Crystal Structure, Spectroscopic, Electrochemical and Antimicrobial Properties of Cu(II) Complex with the Mixed Ligands of 2,9-Dimethyl-1,10-phenanthroline and 4-Hydroxypyridine-2,6-dicarboxylic Acid

摘要

A mononuclear Cu(II) complex with mixed ligands, formulated as [Cu(hypydc)(dmp)]·H₂O (hypydc=4-hydroxypyridine-2,6-dicarboxylate, dmp=2,9-dimethyl-1,10-phenanthroline), was synthesized and well characterized by single crystal X-ray diffraction analysis, as well as spectroscopic (IR, UV-Vis), and electrochemical methods. The Cu(II) atom exhibits a distorted square-pyramidal geometry. Intermolecular OH···O and CH···O hydrogen bonds, π-π stacking interactions and CH···π interactions seem to be effective in the stabilization of the crystal structure. The complex was also evaluated for its antimicrobial activity using in vitro microdilution methods. Six standard bacteria and a strain of Candida albicans were used for the antimicrobial activities. There was a very strong activity against Candida albicans and significant activities against Enterococcus fecalis, Listeria monocytogenes, Bacillus cereus and Staphylococcus aureus, indicating important biological activities of the complex.