Effects of Hydrophobicity of Ethylene Oxide-Propylene Oxide Copolymers on Phase Diagrams of Aqueous Two-Phase Systems and Partition Behaviors of Cephalexin and 7-Aminodeacetoxicephalos- Poranic Acid

摘要

A series of ethylene oxide (EO)-propylene oxide (PO) random co-polymers (EOPO) were used to form aqueous two-phase systems (ATPS) with ammonium sulfate. Effects of EOPO's properties on the phase separation behaviors and on the partition of cephalexin and 7-aminodesacetoxicephalosporanic acid (7-ADCA) in ATPS were investigated. Both the molar mass and molar ratio of EO to PO of EOPO could greatly influence partition behaviors of cephalexin and 7-ADCA as well as the binodal curve of ATPS.