Effects of Solvent and Impurity on Crystal Habit Modification of llα-Hydroxy-16α,17α-epoxyprogesterone

摘要

The effects of solvent and impurity on the crystal habit of llα-hydroxy-16α, 17a-epoxyprogesterone (HEP) grown from solution were studied by scanning electron microscope. Long prismatic crystals were produced when HEP was crystallized from pure acetone and N,N-dimethylformamide, while blocky crystals were produced from pure chloroform by cooling crystallization. One kind of isomorphic impurity, 16α,17a-epoxyprogesterone (EP) was selected to examine its effect on the HEP crystal habit. When the content of EP in the mother liquor is very high (55.45%, solvent free basis), the habit of produced HEP crystals was greatly modified from prismatic to octahedral. The differential scanning calorimetry and X-ray powder diffraction analyses showed that the change of crystal habit was originated from the crystal structure modification.