Clinical significance of CD44v mRNA detection in peripheral blood of patients with hepatocellular carcinoma by RCR

摘要

AIM To study the clinical significance of detecting the CD44v mRNA expression in the blood of patients with hepatocellular carcinoma (HCC). METHODS The expression of CD44v mRAN was detected in blood with RT and diploid PCR and the clinical significance was discussed based on the result of pathological examination and follow-up. RESULTS CD44v mRNA was detected in the blood of 10/15 patients, with a positive rate of 66.67%. In 13 patients who responded to the follow-up, CD44v mRNA expression was positive in 9 cases and negative in 4 cases. Recurrence rate in the patients with positive expression of CD44v mRNA was higher than in those with negative CD44v mRNA expression, and the clinical pathological indexes were also higher in the former than in the latter. CONCLUSION Detection of the CD44v mRNA in blood of the patients with HCC can be used as an adjuvant means for differential diagnosis, prediction and monitoring of the recurrence of HCC.