Treatment of cancerous ascites and radical gastrectomy with intraperitoneal hyperthermic double distilled water and cis-diaminodichloro-platinum perfusion

摘要

AIM To study the effect of intraperitoneal hyperthermic double distilled water and cis-diaminodichloro-platinum (DDP) perfusion in treatment of cancerous ascites and radical gastrectomy. METHODS H_(22) cancer cells (2 x 10~7 tumor cells each mouse) were injected into the peritoneal cavity of LA-CA mice. Five days after the injection, intraperitoneal perfusion of 37℃ isotonic fluid (Group Ⅰ ), simple hyperthermic (43℃) double distilled water (Group Ⅱ), isotonic fluid (group Ⅲ), DDP (group Ⅳ) and hyper-thermic double distilled water perfusion combined with DDP (group Ⅴ) were performed. Based on the experiment from September 1991 through September 1993, intraperitoneal hyperthermic double distilled water perfusion with DDP was used to treat 32 advanced gastric cancer patients after radical gastrectomy. RESULTS In comparison with the control group, the cancer cells in the peritoneal cavity of LACA mice were almost completely destroyied, the ascites was markedly inhibited and the survival time was prolonged, the growth of peritoneal cancerous nodes was reduced in all groups, except the control group. Clinically, after one-year follow-up, all 32 patients with advanced carcinoma got satisfactory results, but the 2-year follow-up was not satisfactory. CONCLUSION The intraperitoneal hyperthermic double distilled water perfusion with DDP inhibited the occurrence of ascites in LACA mice, and prolonged the lifetime of gastric cancer patients after radical gastrectomy.