6,8-dimercaptooctanoic acid derivatives substituted at the 6-S and/or 8-S position with the (3-methylthiopropanoyl) radical and pharmaceutical compositions intended for the treatment of cancerous tumors

摘要

The present invention provides 6,8-Dimercaptooctanoic acid derivatives substituted at the 6-S and/or 8-S position with the (3- methylthiopropanoyl) radical, wherein they correspond to the following formula (I): ##STR1## in which: R represents OR.sub.3 or ##STR2## R.sub. 3 representing a hydrogen atom, a linear or branched alkyl radical, or a radical of the formula ##STR3## n being an integer from 1 to 10 and r' and r", which are identical or different, representing a hydrogen atom, a linear or branched alkyl radical or, taken together, form with the nitrogen atom, a nitrogen-containing heterocycle optionally substituted with an optionally substituted oxygen or nitrogen atom,PP R.sub.5 and R.sub.4, identical or different, represent a hydrogen atom or a linear or branched alkyl radical,PPR.sub.1 and R.sub.2, which are identical or different, represent a hydrogen atom, a radical -- COCH.sub.3 or a radical of formula:PP--CO(CH.sub.2).sub.2 SCH.sub.3 (II)PPwith the proviso that at least one of the radicals R.sub.1 or R.sub.2 represents a radical of formula (II) and the R and S enantiomers and their racemate as well as the salts of the said compounds of formula (I). The present invention also provides pharmaceutical compositions, and method of treatment and prevention of cancerous tumours.