6,8-Dimethylmercaptooctanoic acid derivatives substituted on 6-S and/or 8-S by the 3-methylthiopropanoyl radical and pharmaceutical compositions for the treatment of cancerous tumours

摘要

6,8-Dimercapto-octanoic acid derivatives (I) which are 6-S and/or 8-S substituted by 3-methylthiopropanoyl, and their enantiomers, racemates and salts are new. 6,8-Dimercapto-octanoic acid derivatives of formula (I) which are 6-S and/or 8-S substituted by 3-methylthiopropanoyl, and their R and S enantiomers, racemates and salts are new. R = OR3 or NR'R''; R3 = H, alkyl or -(CR3R4)n-NR'R''; n = 1-10; R', R'' = H or alkyl; or NR'R'' = a N-heterocycle optionally substituted by O or N (sic) which are themselves optionally substituted; R3, R4 = H or alkyl; R1, R2 = H, COCH3 or CO(CH2)2SCH3 (i); provided that at least 1 of R1 and R2 is a group of formula (i).