Chronic Infiltrative Lung Diseases : Value of Gadolinium-Enhanced MRI in the Evaluation of Disease Activity—Early Report

摘要

Study objective: To determine the value of gadolinium-enhanced MRI in the assessment ofndisease activity in chronic infiltrative lung diseases (CILDs).nDesign: Retrospective study.nSetting: University hospital.nMaterials and Methods: Twenty-five consecutive patients with CILD were studied. The followingndiseases were diagnosed: sarcoidosis (n 5 10), bronchiolitis obliterans organizing pneumonian(n 5 3), usual interstitial pneumonia (n 5 4), radiation pneumonia (n 5 2), desquamative inter-nstitial pneumonia (n 5 1), rheumatoid lung (n 5 1), vasculitis (n 5 1), alveolar proteinosis (n 5 1),nbronchioloalveolar carcinoma (n 5 1), and chronic eosinophilic pneumonia (n 5 1). In eachnpatient, the disease activity was assessed by one or more of the following studies: BAL (n 5 18),ngallium-radioisotope lung scanning (n 5 6), serum angiotensin-converting enzyme assay (n 5 10),nand open lung biopsy (n 5 4). T1-weighted breath-hold MRI studies were obtained before andnafter IV injection of gadolinium. The MRI examinations were analyzed to assess the presence ornabsence of lesional enhancement.nResults: The presence of enhanced pulmonary lesions was seen in 14 patients. All of these patientsnhad active disease. Of the 17 patients with active disease, 14 had enhanced lesions, and 3 hadnunenhanced lesions. Pulmonary lesions were not enhanced in any patients with inactive disease.nThe difference was statistically significant (Fisher Exact Test, p < 0.05).nConclusion: Gadolinium-enhanced MRI may prove to be a useful tool in assessing disease activitynin CILDs. (CHEST 2000; 117:1173–1178)