Swiss Science Concentrates

摘要

The use of abundant 3d-metal catalysts for C-H functionaliza-tion is a current hot topic of research. However, enantioselective methods remain underdeveloped. In this work, the authors disclose the preparation of cobalt(Ⅲ) complexes bearing chiral cy-clopentadienyl ligands. To demonstrate their utility as C-H func-tionalization catalysts, the synthesis of dihydroisoquinolones from N-chlorobenzamides was chosen as a benchmark transformation. The excellent enantio- and regioselectivities observed with a large variety of alkenes outperform the best rhodium(Ⅲ) based methods for this reaction. Moreover, the regioselectivity towards alkyl alkenes was shown to be complementary to the one observed with rhodium.