Targeted Screening and Quantification of dl-PCBs and Dioxins in Various Foodstuffs by Programmed-temperature Vaporizer Large-volume Injection Coupled to GC-MS

摘要

In 2009, high concentrations of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (dl-PCBs) were found in soils located near the municipal garbage incinerator of Geneva. The matter of food contamination in this area was raised. Based on exposure criteria, a strategy of analysis of animal fats has been established with farmers in the Geneva area. Most methods of analysis of dl-PCBs, dioxins and furans, are based on gas chromatography coupled to high-resolution mass spectrometry (GC-HRMS) and considered as the reference methodology. An innovative approach was developed by programmed-temperature vaporizer large-volume injection (PTV-LV) and gas chromatography coupled with triple quadrupole mass spectrometry (GC-MS/MS) analysis. This analytical method was validated and was found suitable for screening and quantification of target compounds in animal fats (beef, pork, sheep, etc.). PTV-LV coupled to GC-MS/MS appeared to be a good alternative compared to the GC-HRMS strategy, offering a good compromise between sensitivity, versatility of instrumentation, and economical aspects. A survey of 121 samples was conducted.