...
首页> 外文期刊>Chemistry - A European Journal >Cobalt-Catalyzed Addition Reaction of Organoboronic Acids with Aldehydes: Highly Enantioselective Synthesis of Diarylmethanols
【24h】

Cobalt-Catalyzed Addition Reaction of Organoboronic Acids with Aldehydes: Highly Enantioselective Synthesis of Diarylmethanols

机译:钴催化的有机硼酸与醛的加成反应:二芳基甲醇的高对映选择性合成

获取原文
获取原文并翻译 | 示例
           

摘要

Predicted outcomes: The addition reaction of organoboronic acids with aldehydes in the presence of K2CO3 catalyzed by CoI2/(R,R)-BDPP gives chiral secondary alcohols in excellent yields with 90–99 % enantiomeric excess (see scheme; (R,R)-BDPP=(2R,4R)-(+)-2,4-bis(diphenylphosphino)pentane). This method provides an alternative to prepare an R and S enantiomeric pair by using the same chiral ligand and allows the stereochemical outcome of the reaction to be predicted.
机译:预期的结果:在CoI 2 /(R,R)催化下,在K 2 CO 3 存在下有机硼酸与醛的加成反应-BDPP可以以优异的收率得到手性仲醇,对映体过量90-99%(参见方案;(R,R)-BDPP =(2R,4R)-(+)-2,4-双(二苯基膦基)戊烷)。该方法提供了另一种通过使用相同的手性配体制备R和S对映体对的方法,并可以预测反应的立体化学结果。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号