Catalytic Enantioselective Synthesis of Atropisomeric Indoles with an NC Chiral Axis

摘要

A pivotal role: In the presence of (R)-(−)-5,5′-bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-4,4′-bi-1,3-benzodioxole–PdCl₂ [(R)-SEGPHOS–PdCl₂], 5-endo-hydroaminocyclization of achiral ortho-alkynylanilines proceeds in an enantioselective manner to give optically active, axially chiral indoles (see scheme).