Optically Active Bicyclic N-Heterocycles by Organocatalytic Asymmetric Michael Addition/Cyclization Sequences

摘要

Highly stereoselective one-pot syntheses of various optically active N-heterocyclic bicycles have been developed. The protocols are based on an organocatalytic, asymmetric Michael addition followed by a condensation/cycloaddition sequence to furnish aziridine carbonyls, β-lactams, or octahydrobenzo[c]isoxazoles depending on the reaction conditions and applied nucleophiles.