CENTENARY LECTURE. Bridgehead Unsaturation in Compounds of Nature: A Proper Forum for Unleashing the Potential of Organic Synthesis

摘要

These studies demonstrate that enantioselective routes to natural products containing bridgehead unsaturation can be reliably based on the designed application of [3,3] sigmatropy. The feasibility of such tactics provides the basis for their future adoption in a myriad of contexts that fall well outside the limited arena under discussion here. It is now clear that the exceptional stereocontrol generally available has the potential to be utilized in tandem with other recognized transformations to achieve the rapid scaffolding of complex structure. Synthetic efficiency will thereby be well served.