Charged Cyclodextrin Derivatives as Chiral Selectors in Capillary Electrophoresis

摘要

Capillary electrophoresis has developed explosively over the past few years as a powerful tool for enantiomeric analysis. The fascination with a microanalytical technique which allows the use of nonhazardous chemicals to solve a problem which was recognized as most difficult in separation sciences a few years ago is high. Many successful enantioseparations in CE have been achieved, whereas only a few studies have been performed to understand the basic mechanisms of chiral recognition using this technique. CE is actually not only a good complement but also a valuable alternative to HPLC (probably to GC and SFC too) in analytical scale enantioseparations. Extremely high theoretical plate numbers, raggedness, versatility, cost effectiveness and short analysis time are milestones of this technique. Charged CD derivatives offer a number of important advantages over neutral ones, which favour their rapidly increasing use as chiral selectors. NMR spectroscopy is very valuable for optimization and method development in CE, for a better understanding of the chiral recognition mechanism and sometimes even for correction of results observed in CE. Fundamental studies of the structure of selector-solute complexes will favour a designed synthesis of new types of chiral selectors. CE should provide the impulse for a further increase in activity in supramolecular chemistry where it can serve as a state-of-the-art instrumental technique.