Chiral separation of pharmaceutical compounds with charged cyclodextrins using capillary electrophoresis

摘要

The separation of enantiomeric pairs of compounds by capillary electrophoresis using highly sulfated α-, β-, and γ-Cyclodextrins as chiral selectors is described herein. These charged cyclodextrins have a higher degree of sulfation and narrower heterogeneity than previous cyclodextrin derivatives. CE analyses using highly sulfated cyclodextrins produce improved resolution of a wide variety of chiral drugs, particulaly neutral compounds and amines. The highly sulfated α-, β-, and γ-cyclodextrins produce separations which complement each other to further expand the number of neutral and basic drugs that can be resolved by capillary electrophorsis.