The doping effect of fluorinated aromatic hydrocarbon solvents on the performance of common olefin metathesis catalysts: application in the preparation of biologically active compounds

摘要

Aromatic fluorinated hydrocarbons, used as solvents for olefin metathesis reactions, catalysed by standard commercially available Ru precatalysts, allow substantially higher yields to be obtained, especially of challenging substrates, including natural and biologically active compounds.rnRecent decades have seen burgeoning interest in olefin metathesis, as witnessed by the rapidly growing number of elegant applications. Using this tool, chemists can now efficiently synthesize an impressive range of molecules that only a decade ago required significantly longer and more tedious routes. The development of efficient and selective catalysts 1-3 is the key to the widespread application of olefin metathesis in organic synthesis.