Modular synthesis of multivalent glycoarchitectures and their unique selectin binding behavior

摘要

Hyperbranched polyglycerols (HPGs) are ideal scaffolds for the multivalent presentation of saccharides, due to their biocompatible, carbohydrate-like properties; here, we report the conjugation of galactose sugar moieties to HPG, and the multivalent effect of these constructs on selectin binding.rnCarbohydrates play a significant role in biological systems, spreading from cellular recognition and adhesion to cell growth and differentiation. Wide interest has been devoted to the interplay of cell-surface receptors with their corresponding binding carbohydrate moieties. Unfortunately, most carbohydrate-receptor interactions are weak (dissociation constants are in the millimolax concentration range) and in order to compensate for their low binding affinity, different strategies based on multivalent interactions have been designed, including carbohydrate clusters, glycopolymers and glycopeptides.