Solvents for ring-closing metathesis reactions

摘要

A study of the influence of eight diverse solvents on a Grubbs II-catalysed ring-closing metathesis (RCM) reaction reveals a complex dependence of the different reaction steps on the solvent and suggests acetic acid as a useful solvent for RCM reactions.rnOlefin metathesis reactions catalysed by the 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene ruthenium complex Ru (Grubbs II catalyst) continue to be of great importance (the 1999 paper describing the preparation of this complex has been cited ca. 1300 times). Despite the numerous mechanistic and computational studies of these reactions, relatively few publications have focused on solvent effects, even though solvents influence both the rate and cis/trans stereoselectivity.