Chiral detection at a liquid-liquid interface

摘要

Chiral ion transfer and detection at a liquid-liquid interface using chiral stationary phases such as cyclodextrins; could lead to alternative methods of chiral detection and separation.rnChiral separation and detection, in industry, are routinely performed using chiral chromatography as a method of choice. Interrogation of chiral ionic interactions is crucial in drug discovery and biochemical processes. We are, therefore looking at simple, appropriate methods for facilitating these studies. Some groups have reported traditional electro-analytical potentiometric sensors using chiral ionophores, for chiral detection. Interactions at a liquid-liquid interface interrogated by ion-amperometric measurement rather than potentiometric measurements, are more sensitive, allow access to the estimation of enantioselective Gibbs free energies of transfer between an aqueous and a lipophilic phase and can be adapted to enable separation and detection. In this communication we demonstrate facilitated ion-transport using ion-amperometry, at a liquid-liquid interface (interface between two immiscible electrolytes, ITIES) as a suitable method for studying chiral interactions.