Ultrasonication-assisted spray ionization mass spectrometry for on-line monitoring of organic reactions

摘要

A straightforward on-line monitoring of organic reactions by ultrasonication-assisted spray ionization mass spectrometry (UASI MS) is demonstrated in this work. Ultrasonication has been employed to accelerate organic syntheses and enzymatic reactions. For example, high biodiesel yields can be obtained through the transesterification of vegetable oils in the presence of alcohol and base catalyst under ultrasonication within a much shorter time than those obtained through conventional approaches. Under ultrasonic mixing, smaller droplet sizes of alcohol/oil dispersions accelerate the reaction, leading to high transesterification yield.