Domino allylic amination/Sonogashira/heterocyclisation reactions: palladium-catalysed three-component synthesis of pyrroles

摘要

Three-component reactions with 3,4-diiodoalk-2-enoic derivatives, primary amines, and terminal alkynes proceeded to give trisubstituted pyrroles in fair to good yields in the presence of palladium and copper catalysts under mild reaction conditions.rnPyrroles are key structural motifs in various classes of natural products, synthetic Pharmaceuticals and electrically conducting polymers and are also valuable synthetic intermediates. In addition to a number of traditionally employed approaches, several transition-metal-catalyzed methods have recently emerged for the synthesis of pyrroles.