Facilitated photochemical cleavage of benzylic C-O bond.Application to photolabile hydroxyl-protecting group design

摘要

A new photolabile hydroxyl-protecting group has been developed by introducing a dimethylamino group to the meta position of an aromatic ring of the traditional trityl (Tr) protecting group. Protecting groups are indispensable tools in organic chemistry. Among various protecting groups, photolabile protecting groups (PPGs) have valuable and unique features. They are typically removed under mild conditions by light without using any chemical reagents and are capable of releasing substrates in a spatially and temporally controlled manner.