Immobilized unfolded cytochrome c acts as a catalyst for dioxygen reduction

摘要

Unfolding turns immobilized cytochrome c into a His-His ligated form endowed with catalytic activity towards O_2, which is absent in the native protein. Dioxygen could be used by naturally occurring unfolded cytochrome c as a substrate for the production of partially reduced oxygen species (PROS) contributing to the cell oxidative stress.