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Site-selective DNA hydrolysis induced by a metal-free peptide nucleic acid-cyclen conjugate

机译：无金属肽核酸-周期蛋白偶联物诱导的定点DNA水解

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摘要

A metal-free artificial restriction DNA cutter which is composed of cyclen and classical peptide nucleic acid (PNA) was synthesized. Analysis of DNA cleavage products indicates the site-selective hydrolysis.
机译：合成了由周期蛋白和经典肽核酸（PNA）组成的无金属人工限制性DNA切割剂。 DNA切割产物的分析表明位点选择性水解。

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  • 来源
    《Chemical Communications》 |2011年第39期|p.11059-11061|共3页
  • 作者

    Ming-Qi Wang; Jun-Liang Liu; Jing-Yi Wang; Da-Wei Zhang; Ji Zhang; Frank Streckenbach; Zhuo Tang; Hong-Hui Lin; Yan Liu; Yu-Fen Zhao; Xiao-Qi Yu;

  • 作者单位

    Key Laboratory of Green Chemistry and Technology (Ministry of Education), College of Chemistry, Sichuan University, Chengdu,610064, P. R. China;

    Key Laboratory of Green Chemistry and Technology (Ministry of Education), College of Chemistry, Sichuan University, Chengdu,610064, P. R. China;

    Key Laboratory of Green Chemistry and Technology (Ministry of Education), College of Chemistry, Sichuan University, Chengdu,610064, P. R. China;

    Key Laboratory of Bio-Resources and Eco-Environment (Ministry of Education), College of Life Sciences, Sichuan University, Chengdu,Sichuan, 610064, P. R. China;

    Key Laboratory of Green Chemistry and Technology (Ministry of Education), College of Chemistry, Sichuan University, Chengdu,610064, P. R. China;

    Natural Products Research Center, Chengdu Institute of Biology,Chinese Academy of Sciences, 610041, P. R. China;

    Natural Products Research Center, Chengdu Institute of Biology,Chinese Academy of Sciences, 610041, P. R. China;

    Key Laboratory of Bio-Resources and Eco-Environment (Ministry of Education), College of Life Sciences, Sichuan University, Chengdu,Sichuan, 610064, P. R. China;

    College of Chemistry and Chemical Engineering, Xiamen University,Xiamen, 361005, P. R. China;

    College of Chemistry and Chemical Engineering, Xiamen University,Xiamen, 361005, P. R. China;

    Key Laboratory of Green Chemistry and Technology (Ministry of Education), College of Chemistry, Sichuan University, Chengdu,610064, P. R. China;

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  • 入库时间 2022-08-17 13:22:49

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