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Site-selective DNA hydrolysis induced by a metal-free peptide nucleic acid-cyclen conjugate

机译：无金属肽核酸-周期蛋白偶联物诱导的定点DNA水解

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摘要

A metal-free artificial restriction DNA cutter which is composed of cyclen and classical peptide nucleic acid (PNA) was synthesized. Analysis of DNA cleavage products indicates the site-selective hydrolysis.

机译：合成了由周期蛋白和经典肽核酸（PNA）组成的无金属人工限制性DNA切割剂。 DNA切割产物的分析表明位点选择性水解。

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Wang Ming-Qi; Liu Jun-Liang; Wang Jing-Yi; Zhang Da-Wei; Zhang Ji; Streckenbach Frank; Tang Zhuo; Lin Hong-Hui; Liu Yan; Zhao Yu-Fen; Yu Xiao-Qi;
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专利

1. Site-selective DNA hydrolysis induced by a metal-free peptide nucleic acid-cyclen conjugate [J] . Ming-Qi Wang, Jun-Liang Liu, Jing-Yi Wang, Chemical Communications . 2011,第39期

机译：无金属肽核酸-周期蛋白偶联物诱导的定点DNA水解
2. Thiazole orange-conjugated peptide nucleic acid for fluorescent detection of specific DNA sequences and site-selective photodamage [J] . Tanaka Makiko, Shigi Narumi, Sumaoka Jun, RSC Advances . 2014,第108期

机译：噻唑橙缀合的肽核酸，用于特定DNA序列的荧光检测和位点选择性光损伤
3. Sequence selective hydrolysis of linear DNA using conjugates of Zr(IV) complexes and peptide nucleic acids [J] . Zelder FH., Mokhir AA., Kramer R. Inorganic Chemistry: A Research Journal that Includes Bioinorganic, Catalytic, Organometallic, Solid-State, and Synthetic Chemistry and Reaction Dynamics . 2003,第26期

机译：使用Zr（IV）配合物和肽核酸结合物对线性DNA进行序列选择性水解
4. Sequence-Specific Cleavage of DNA by Peptide Nucleic Acids Conjugated with Metal Complexes [C] . Toru Sugiyama, Keiko Ninomiya, Yasutada Imamura Japanese peptide symposium . 2010

机译：用金属络合物缀合的肽核酸的DNA序列特异性切割
5. Inhibition of amikacin resistance in bacteria by a peptide conjugated 2',4'-bridged nucleic acid-NC-DNA hybrid oligomer [D] . Lopez, Christina. 2016

机译：肽缀合的2'，4'-桥核酸-NC-DNA杂合寡聚物抑制细菌对丁胺卡那霉素的抗性
6. A DNA-conjugated small molecule catalyst enzyme mimic for site-selective ester hydrolysis [O] . Moira L. Flanagan, A. Emilia Arguello, Drew E. Colman, 2018

机译：DNA缀合的小分子催化酶模拟位点选择性酯水解
7. Site-selective DNA hydrolysis induced by a metal-free peptide nucleic acid-cyclen conjugate [O] . Wang Ming-Qi（Sichuan Univ Coll Chem）, Liu Jun-Liang（Sichuan Univ Coll Chem）, Wang Jing-Yi（Sichuan Univ Coll Chem）, 2011

机译：无金属肽核酸-周期蛋白偶联物诱导的定点DNA水解
8. In Vitro Assessment of a Peptide Nucleic Acid (PNA) - Peptide Conjugate Labeled With an Auger-Emitting Radionuclide for Prostate Cell Killing [R] . Wilbur, S. D. 2005

机译：体外评估肽核酸（pNa） - 用俄歇发射放射性核素标记的肽缀合物用于前列腺细胞杀伤

Site-selective DNA hydrolysis induced by a metal-free peptide nucleic acid-cyclen conjugate

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