Encoded dendrimers with defined chiral composition via 'click' reaction of enantiopure building blocks

摘要

Dendrimers with end-groups of defined chiral composition have been prepared from alkyne functional enantio-pure building blocks obtained by selective enzymatic (ADH) ketone reductions using click chemistry. Optical rotation and enantioselective enzymatic modification is in agreement with the chiral composi-tion of the dendrimers and permits unique molecular-level encoding of stereoisomeric dendritic libraries.