Anticancer gold(I)-phosphine complexes as potent autophagy-inducing agentsf

摘要

A panel of anticancer gold(I)-phosphine complexes exhibit significant autophagy-inducing properties in cancer cells. Gold(I) complexes exhibit significant biological activities that can be used for the development of novel therapeutic agents. Studies on anticancer gold(I)-phosphine complexes have continued to accelerate over the years since the discovery of auranofin (S-triethylphosphine-gold(I)-2,3,4,6-tetra-O-acetyl-l-thio-β-D-glucopyranoside), a drug used for the treatment of rheumatoid arthritis which also exhibits anticancer properties. A number of novel gold(I)-phosphine complexes display a wide spectrum of anticancer activity, especially in some cisplatin-resistant cell lines.