Copper-mediated trifluoromethylation of arylboronic acids by trifluoromethyl sulfonium salts

摘要

The ligand-free trifluoromethylation of arylboronic acids with a [Ph_2SCF_3]~+[OTf]~-/Cu(0) system has been carefully investigated. Aryl-, alkenyl- and heteroarylboronic acids with a variety of functional groups were suitable substrates for this reaction. It is suggested that a CuCF_3, species is formed under the reaction conditions. Trifluoromethylated compounds have been widely used in the fields of biochemistry and materials science. Their unique physical and biological properties, the direct result of the fluorine substituents, have made them suitable as pharma-ceuticals, agricultural chemicals, polymers and liquid crystals.1 Trifluoromethylated compounds are often more difficult to synthesize than their non-fluorinated analogues. Although there are many approaches, the development of more efficient methodology to meet the increasing demands for fluorinated chemicals is a high priority.