Direct imaging and chemical analysis of unstained DNA origami performed with a transmission electron microscopef

摘要

Here, we report a simple and rapid characterisation technique combining physical and chemical analysis for DNA origami with conventional TEM. DNA nanotechnology has attracted great interest for a broad range of applications: an ideal building block for reliable nanoscale patterning, a DNA cage for drug delivery and DNA computing. The DNA's unique structural features have been exploited to design various 2D and 3D architectures, but for practical applications, it is essential to deeply examine these complex nano-scale structures.