Detection of DNA base variation and cytosine methylation at a single nucleotide site using a highly sensitive fluorescent probe

Jean-Louis H. A. Duprey; Zheng-yun Zhao; Dario M. Bassani; Jack Manchester; Joseph S. Vyle; James H. R. Tucker

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Detection of DNA base variation and cytosine methylation at a single nucleotide site using a highly sensitive fluorescent probe

机译：使用高度灵敏的荧光探针检测单核苷酸位点的DNA碱基变异和胞嘧啶甲基化

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A fluorescent DNA probe containing an anthracene group attached via an anucleosidic linker can identify all four DNA bases at a single site as well as the epigenetic modification C/5-MeC via a hybridisation sensing assay.

机译：含有通过无核苷连接子连接的蒽基的荧光DNA探针可以通过杂交传感测定法鉴定单个位点上的所有四个DNA碱基以及表观遗传修饰C / 5-MeC。

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《Chemical Communications》 |2011年第23期|p.6629-6631|共3页
作者
Jean-Louis H. A. Duprey; Zheng-yun Zhao; Dario M. Bassani; Jack Manchester; Joseph S. Vyle; James H. R. Tucker;
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School of Chemistry, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK;

School of Chemistry, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK;

Institut des Sciences Moleculaires, CNRS UMR 5255, Universite Bordeaux 1, 351 Cours de la Liberation, F-33405 Talence, France;

School of Chemistry, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK;

School of Chemistry and Chemical Engineering, David Keir Building, Queen's University Belfast (QUB), Stranmillis Rd, Belfast BT9 5AG, UK;

School of Chemistry, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK;

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1. Fluorescent detection of single nucleotide polymorphism utilizing a hairpin DNA containing a nucleotide base analog pyrrolo-deoxycytidine as a fluorescent probe [J] . Zhang H., Wang M., Gao Q., Talanta: The International Journal of Pure and Applied Analytical Chemistry . 2011,第3期

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2. Sequence-selective Modification of DNA Cytosine by Using Junction-forming DNA Probes and Its Application to the Detection of Single Cytosine Methylation [J] . Kenta TAKANASHI, Teru KATO Analytical Sciences . 2014,第3期

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Detection of DNA base variation and cytosine methylation at a single nucleotide site using a highly sensitive fluorescent probe

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