Endosome-escapable magnetic poly(amino acid) nanoparticles for cancer diagnosis and therapy

摘要

Endosome-escapable poly(amino acid) nanoparticles composed of iron oxide nanocrystals and anticancer drugs were prepared and demonstrated high T_2 relaxivity coefficients and higher efficacy attributed to the endosomolytic ability of the conjugated histidine moiety. The multifunctional nanoparticles for simultaneous diagnosis and therapy have garnered in the form of monolithic or nanocapsules increasing attention over the past several years.~(1-3) Especially, the nanocapsule type of multifunctional nanoparticles are formed by encapsulating a number of nanocrystals of superparamagnetic iron oxide and anticancer drugs within amphiphilic polymers for MR imaging and chemotherapy of cancer.~2