I-Motif formation in gene promoters: unusually stable formation in sequences complementary to known G-quadruplexes

John A. Brazier; Arti Shah; Geoffrey D. Brown

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I-Motif formation in gene promoters: unusually stable formation in sequences complementary to known G-quadruplexes

机译：基因启动子中的I-基序形成：与已知G-四链体互补的序列中异常稳定的形成

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I-motif formation has been confirmed in a number of gene promoter sequences known to form G-quadruplex structures. I-motif formation can occur close to physiological temperature and pH for h-tert and PDGF-A. The i-motif structure formed by a HIF-lα promoter sequence shows unexpected stability near neutral pH.

机译：I-基序的形成已在许多已知形成G-四链体结构的基因启动子序列中得到证实。 I-基序的形成可发生在接近h-tert和PDGF-A的生理温度和pH值时。由HIF-1α启动子序列形成的i-基序结构在中性pH附近显示出意外的稳定性。

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《Chemical Communications》 |2012年第87期|p.10739-10741|共3页
作者
John A. Brazier; Arti Shah; Geoffrey D. Brown;
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School of Pharmacy, University of Reading, Whiteknights, Reading, Berks, RG6 6AD;

School of Pharmacy, University of Reading, Whiteknights, Reading, Berks, RG6 6AD;

Department of Chemistry, University of Reading, Whiteknights, Reading, Berks, RG6 6 AD;

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入库时间 2022-08-17 13:21:04

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机译：血小板衍生的生长因子受体β核心启动子核酸酶超敏元件中重叠的G-四链体和i-基序的后果可以解释突变的意想不到的作用，并为小分子选择性靶向两种结构提供下调基因表达的机会。
2. Formation of an i-Motif Structure by a Self-Complementary DNA Sequence [J] . Shanteri Singh, R. V. Hosur Journal of the American Chemical Society . 1995,第50期

机译：通过自我互补的DNA序列形成i-母题结构
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4. Formation and dissociation of the tetramolecular DNA i-motif by the sequences d(XnC4Ym) in the gas- and solution-phase [C] . Xinhua Guo, Yanwei Cao, Yujiao Qin, International Mass Spectrometry Conference . 2014

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5. The effect of molecular crowding on the stability of human c-MYC promoter sequence i-motif at neutral pH. [D] . Cui, Jingjing. 2013

机译：分子拥挤对中性pH下人c-MYC启动子序列i-motif稳定性的影响。
6. The Consequences of Overlapping G-Quadruplexes and i-Motifs in the Platelet-Derived Growth Factor Receptor β Core Promoter Nuclease Hypersensitive Element Can Explain the Unexpected Effects of Mutations and Provide Opportunities for Selective Targeting of Both Structures by Small Molecules To Downregulate Gene Expression [O] . Robert V. Brown, Ting Wang, Venkateshwar Reddy Chappeta, -1

机译：血小板衍生的生长因子受体β核心启动子核酸酶超敏元件中重叠的G-四链体和i-基序的后果可以解释突变的意想不到的作用并为小分子选择性靶向两种结构提供下调基因表达的机会。
7. Formation of an i-Motif Structure by a Self-Complementary DNA SequenceJ.Am.Chem.Soc.1995,117, 12637−12638 [O] . Shanteri Singh, R. V. Hosur 1996

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8. Genetic Transformation Systems for Characterization of Gene Promoters in MarineAlgae [R] . Smith, G. J. 1995

机译：遗传转化系统表征海藻中的基因启动子

I-Motif formation in gene promoters: unusually stable formation in sequences complementary to known G-quadruplexes

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