I_2 promoted domino oxidative cyclization for one-pot synthesis of 2-acylbenzothiazoles via metal-free sp~3 C-H functionalization

摘要

An I_2 promoted domino protocol was developed to construct 2-acylbenzothiazoles from simple and readily available aromatic ketones/unsaturated methyl ketones and o-aminobenzenethiols. The reaction proceeded smoothly under metal-free and peroxide-free conditions. In recent years, catalytic C-H functionalization, especially an sp3 C-H bond, has drawn considerable interest.1 Many excellent results have been achieved based on the transition-metal-catalyzed approach. Very recently, iodide catalyzed C-H bond functionalization has been established.