Covalent attachment of antagonists to the α7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides

Joseph I. Ambrus; Jill I. Halliday; Nicholas Kanizaj; Nathan Absalom; Kasper Harpsoe; Thomas Balle; Mary Chebib; Malcolm D. McLeod

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Covalent attachment of antagonists to the α7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides

机译：拮抗剂与α7烟碱乙酰胆碱受体的共价结合：取代马来酰亚胺的合成和反应性

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The 3-methylmaleimide congeners of the natural product methyllycaconitine (MLA) and an analogue covalently attach to functional cysteine mutants of the α7 nicotinic acetylcholine receptor (nAChR).

机译：天然产物甲基可卡因碱（MLA）和类似物的3-甲基马来酰亚胺同类物与α7烟碱乙酰胆碱受体（nAChR）的功能性半胱氨酸突变体共价连接。

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《Chemical Communications》 |2012年第53期|p.6699-6701|共3页
作者
Joseph I. Ambrus; Jill I. Halliday; Nicholas Kanizaj; Nathan Absalom; Kasper Harpsoe; Thomas Balle; Mary Chebib; Malcolm D. McLeod;
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Research School of Chemistry, Australian National University,Canberra, ACT 0200, Australia;

Research School of Chemistry, Australian National University,Canberra, ACT 0200, Australia;

Research School of Chemistry, Australian National University,Canberra, ACT 0200, Australia;

Faculty of Pharmacy, The University of Sydney, Sydney,NSW 2006, Australia;

NNF Centre for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark;

Department of Drug Design and Pharmacology,Faculty of Health and Medical Sciences, University of Copenhagen,Universitetsparken 2, 2100 Copenhagen, Denmark;

Faculty of Pharmacy, The University of Sydney, Sydney,NSW 2006, Australia;

Research School of Chemistry, Australian National University,Canberra, ACT 0200, Australia;

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5. Agonist and antagonist interactions with the nicotinic acetylcholine receptor. [D] . Hong, Filbert Hui-pek. 2004

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Covalent attachment of antagonists to the α7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides

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