Asymmetric assembly of 2-oxindole and α-angelica lactone units to construct vicinal quaternary chiral centers

摘要

The first organocatalytic asymmetric assembly of Morita-Baylis-Hillman carbonates of isatins and a-angelica lactone has been studied, affording multifunctional products containing two valuable pharmacophores and vicinal quaternary chiral centers in high stereoselectivity (up to 92% ee, dr > 95 : 5).