手性磷酸催化环状 N-磺酰亚胺与2-苯基吲哚的不对称傅克烷基化反应

摘要

An asymmetric Friedel-Crafts Alkylation reaction of cyclic N-Sulfimines with 2-phenyl-1 H-indoles has been researched under the catalysis of chiral phosphoric acids as an organocatalyst,affording Friedel-Crafts reaction products in high yields (up to 98% yield)and with moderated to high enantioselectivities of up to 81 % ee.%主要研究了环状 N-磺酰亚胺与2-苯基吲哚在手性磷酸催化下的不对称傅克烷基化反应。通过对多种催化剂的筛选及反应条件的优化，最终获得较高产率（72％—8％）和中等对映选择性（37％—1％）的不对称傅克烷基化反应产物。