Ligand denticity controls enantiomeric preference in DNA-based asymmetric catalysis

摘要

DNA-based catalysis can be used to control the enantioselectivity of copper-catalysed Diels-Alder and Friedel-Crafts reactions to produce either enantiomer of the product by changing the denticity of the ligand coordinated to the Cu(n) ion, even though the DNA adopts a right handed helical conformation only.