Chemical proteomics-driven discovery of oleocanthal as an Hsp90 inhibitor

Luigi Margarucci; Maria Chiara Monti; Chiara Cassiano; Matteo Mozzicafreddo; Mauro Angeletti; Raffaele Riccio; Alessandra Tosco; Agostino Casapullo

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Chemical proteomics-driven discovery of oleocanthal as an Hsp90 inhibitor

机译：化学蛋白质组学驱动的油橄榄素作为Hsp90抑制剂的发现

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Hsp90, a key target in cancer therapy, has been identified as the main partner of oleocanthal, an olive oil bioactive compound. A combination of chemical and biological assays disclosed its mechanism of action at the molecular level.

机译：Hsp90是癌症治疗中的关键靶标，已被确定为橄榄油生物活性化合物oleocanthal的主要伴侣。化学和生物学分析的结合揭示了其在分子水平上的作用机理。

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《Chemical Communications》 |2013年第52期|5844-5846|共3页
作者
Luigi Margarucci; Maria Chiara Monti; Chiara Cassiano; Matteo Mozzicafreddo; Mauro Angeletti; Raffaele Riccio; Alessandra Tosco; Agostino Casapullo;
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Dipartimento di Farmacia, Universita degli Studi di Salerno, Via Ponte don Melillo, 84084 Fisciano, Italy;

Dipartimento di Farmacia, Universita degli Studi di Salerno, Via Ponte don Melillo, 84084 Fisciano, Italy;

Dipartimento di Farmacia, Universita degli Studi di Salerno, Via Ponte don Melillo, 84084 Fisciano, Italy;

Scuola di Bioscienze e Biatecnologie, Universita degli Studi di Camerino, via Gentile Ⅲ da Varano, 62032 Camerino, Italy;

Scuola di Bioscienze e Biatecnologie, Universita degli Studi di Camerino, via Gentile Ⅲ da Varano, 62032 Camerino, Italy;

Dipartimento di Farmacia, Universita degli Studi di Salerno, Via Ponte don Melillo, 84084 Fisciano, Italy;

Dipartimento di Farmacia, Universita degli Studi di Salerno, Via Ponte don Melillo, 84084 Fisciano, Italy;

Dipartimento di Farmacia, Universita degli Studi di Salerno, Via Ponte don Melillo, 84084 Fisciano, Italy;

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入库时间 2022-08-17 13:18:26

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1. Erratum: Tricyclic series of heat shock protein 90 (Hsp90) inhibitors part I: Discovery of tricyclic imidazo[4,5-c]pyridines as potent inhibitors of the Hsp90 molecular chaperone (Journal of Medicinal Chemistry (2011) 54 (7206-7219) DOI: 10.1021/jm200784m) [J] . Vallée F., Carrez C., Pilorge F., Journal of Medicinal Chemistry . 2012,第1期

机译：勘误：三环系列热休克蛋白90（Hsp90）抑制剂第一部分：三环咪唑并[4,5-c]吡啶类作为Hsp90分子伴侣的有效抑制剂的发现（药物化学杂志（2011）54（7206-7219） DOI：10.1021 / jm200784m）
2. Tricyclic series of heat shock protein 90 (HSP90) inhibitors part I: Discovery of tricyclic imidazo[4,5-c]pyridines as potent inhibitors of the hsp90 molecular chaperone [J] . Vallée F., Carrez C., Pilorge F., Journal of Medicinal Chemistry . 2011,第20期

机译：三环系列热休克蛋白90（HSP90）抑制剂第I部分：发现三环咪唑并[4,5-c]吡啶类化合物作为hsp90分子伴侣的有效抑制剂
3. Discovery and Optimization of Small Molecules Targeting the Protein-Protein Interaction of Heat Shock Protein 90 (Hsp90) and Cell Division Cycle 37 as Orally Active Inhibitors for the Treatment of Colorectal Cancer [J] . Wang Lei, Jiang Jingsheng, Zhang Lixiao, Journal of Medicinal Chemistry . 2020,第3期

机译：靶向热休克蛋白90（HSP90）和细胞分裂周期37的蛋白质 - 蛋白质与细胞分裂循环37的蛋白质 - 蛋白质相互作用的发现和优化作为口服活性抑制剂治疗结直肠癌
4. In silico identification of potent inhibitors of heat shoek protein 90(Hsp90)from Indonesian natural product compounds as a novel approach to treat ebola virus disease [C] . Muhammad Chandra Haikal, Mochammad Arfln Fardiansyah Nasution, Linggih Saputro Joint Conference on Chemistry . 2019

机译：从印度尼西亚天然产物化合物中硅质鉴定热沙蛋白90（HSP90）的有效抑制剂作为一种治疗埃博拉病毒疾病的新方法
5. Natural product inhibitors of Hsp90: Potential leads for drug discovery [D] . Amolins, Michael W. 2009

机译：Hsp90的天然产物抑制剂：药物发现的潜在线索
6. Chemically Accessible Hsp90 Inhibitor That Does NotInduce a Heat Shock Response [O] . Yen Chin Koay, Jeanette R. McConnell, Yao Wang, 2014

机译：化学可及的Hsp90抑制剂引起热冲击反应
7. Discovery of Hsp90 small molecule inhibitors and explore the interaction between Hsp90 and B3 [O] . 马顺 2013

机译：Hsp90小分子抑制剂的发现并探索Hsp90与B3之间的相互作用

Chemical proteomics-driven discovery of oleocanthal as an Hsp90 inhibitor

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