A strategy for antimicrobial regulation based on fluorescent conjugated oligomer-DNA hybrid hydrogels

摘要

New fluorescent oligo(phenylene ethynylene)-DNA hydrogels have been prepared and used for the controllable biocidal activity driven by DNase. This study opens a new way of controllable drug release and antimicrobial regulation. Hydrogels are a network of polymer chains that are water-insoluble and also possess a degree of flexibility very similar to natural tissue. They usually show a good biocompatibility when in contact with blood, body fluids and human tissues.