A Pt(Ⅱ)-Dip complex stabilizes parallel c-myc G-quadruplex

Jintao Wang; Kaihui Lu; Shuguang Xuan; Zaozhen Toh; Dawei Zhang; Fangwei Shao

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A Pt(Ⅱ)-Dip complex stabilizes parallel c-myc G-quadruplex

机译：Pt（Ⅱ）-Dip配合物稳定平行c-myc G-四链体

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A new G-quadruplex (GQ) stabilizer. [Pt(Dip)_2](PF_6)_2 (Dip: 4,7-diphenyl-1,10-phenanthroline), is prepared by the microwave irradiation method. The complex can highly stabilize G-quadruplex, but has negligible interactions with duplex DNA. Aromatic anchors on the polypyridyl ligands bestow the stabilizer with a high binding preference towards parallel GQ.

机译：新型的G-四链体（GQ）稳定剂。通过微波照射法制备[Pt（Dip）_2]（PF_6）_2（Dip：4，7-二苯基-1，10-菲咯啉）。该复合物可以高度稳定G-四链体，但与双链体DNA的相互作用可忽略不计。聚吡啶基配体上的芳香族锚定剂赋予稳定剂对平行GQ的高结合偏好。

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来源
《Chemical Communications》 |2013年第42期|4758-4760|共3页
作者
Jintao Wang; Kaihui Lu; Shuguang Xuan; Zaozhen Toh; Dawei Zhang; Fangwei Shao;
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Division of Chemistry and Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore;

Division of Chemistry and Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore;

Division of Chemistry and Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore;

Division of Chemistry and Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore;

Division of Chemistry and Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore;

Division of Chemistry and Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore;

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A Pt(Ⅱ)-Dip complex stabilizes parallel c-myc G-quadruplex

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