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Ganglioside-embedding small bicelles for probing membrane-landing processes of intrinsically disordered proteins

机译：嵌入神经节苷脂的小细胞用于探测内在无序蛋白的膜着陆过程

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摘要

We successfully displayed a series of gangliosides on small bicelles with a uniform confined size, offering nanoscale standardized membrane mimics for spectroscopic characterization of weak encounter complexes formed between ganglioside clusters and amyloidogenic proteins. This enabled probing of initial membrane-landing processes of ot-synuclein as a therapeutic target by NMR spectroscopy.
机译：我们成功地在大小一致的小型Bicell上展示了一系列神经节苷脂，提供了纳米级标准化膜模拟物，用于光谱表征神经节苷脂簇和淀粉样蛋白之间形成的弱相遇复合物。这使得能够通过NMR光谱探测作为治疗靶点的ot-突触核蛋白的初始膜着陆过程。

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  • 来源
    《Chemical Communications》 |2013年第12期|1235-1237|共3页
  • 作者

    Takumi Yamaguchi; Tsuyoshi Uno; Yoshinori Uekusa; Maho Yagi-Utsumi; Koichi Kato;

  • 作者单位

    Institute for Molecular Science and Okazaki Institute fir Integrative Bioscience, National Institutes of Natural Sciences, 5-1 Higashiyama Myodaiji Okazaki 444-8787, Japan Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, 467-8603, Japan;

    Institute for Molecular Science and Okazaki Institute fir Integrative Bioscience, National Institutes of Natural Sciences, 5-1 Higashiyama Myodaiji Okazaki 444-8787, Japan Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, 467-8603, Japan;

    Institute for Molecular Science and Okazaki Institute fir Integrative Bioscience, National Institutes of Natural Sciences, 5-1 Higashiyama Myodaiji Okazaki 444-8787, Japan Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, 467-8603, Japan;

    Institute for Molecular Science and Okazaki Institute fir Integrative Bioscience, National Institutes of Natural Sciences, 5-1 Higashiyama Myodaiji Okazaki 444-8787, Japan Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, 467-8603, Japan;

    Institute for Molecular Science and Okazaki Institute fir Integrative Bioscience, National Institutes of Natural Sciences, 5-1 Higashiyama Myodaiji Okazaki 444-8787, Japan Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, 467-8603, Japan;

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  • 入库时间 2022-08-17 13:17:57

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