Processes to avoid deficiency of a hemodialysis patient access site, to treat vascular grafts, to prevent failure of vascular grafts made with inhibiting the synthesis of extracellular matrix proteins in human tissue and collagen in restenosis, to treat sclerotic disorders, to reduce sclerotic disorders, to reduce sclerotic disorders scar formation in a human tissue, and inhibit the formation of fibrous connective tissue in a human, and, composition

摘要

"PROCESSES TO AVOID DEFICIENCY OF A HEMODYALYSIS ACCESS SITE OF A HEMODYALYSIS PATIENT, TREAT VASCULAR GRAFT, PREVENT FAILURE OF VASCULAR GRAFTS MADE, INHIBIT THE SYNTHESIS OF DETECTIVE DETECTIONS OF DETECTIVE EMITTERES OF DETECTIVE DETECTIONS OF DETECTIVE DETECTIONS REDUCE SCAR FORMATION IN A HUMAN TISSUE, AND INHIBIT FIBROUS CONNECTIVE TISSUE FORMATION IN A HUMAN, AND, COMPOSITION ". A process and compounds are provided to inhibit the synthesis of extracellular matrix proteins. The compounds of the invention comprise specific oligonucleotides for nuclear proto-oncogenes. Preferably, the oligonucleotides of the invention are selected from the group consisting of c-myc and c-myb and are administered locally. The invention finds use in the treatment of a variety of disorders, including sclerotic disorders and restenosis, associated with the inappropriate synthesis of proteins in the extracellular matrix, particularly collagen.