Copper-catalyzed C-N bond formation through C-H/N-H activation: a novel approach to the synthesis of multisubstituted ureas

摘要

A copper-catalyzed cross-dehydrogenative coupling reaction that involves C-H activation of formamides and N-H activation of N-alkoxy amides has been developed. This protocol affords a novel approach to the synthesis of multisubstituted ureas under mild conditions. N-acyl ureas are important structural units that are found in various bioactive compounds such as those with anti-inflammatory, hypnotic, analgesic and antitumor properties.