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首页> 外文期刊>Chemical Communications >Crown ethers attenuate aggregation of amyloid beta of Alzheimer's disease
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Crown ethers attenuate aggregation of amyloid beta of Alzheimer's disease

机译：冠醚减弱阿尔茨海默氏病的淀粉样β的聚集

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摘要

In this report, we reasoned that non-covalent modification of amyloid beta (Aβ) by crown ethers could inhibit its aggregation. We demonstrated that PiB-C, a conjugate PiB and crown ether, could significantly reduce the aggregation in vitro. Additionally, two-photon imaging showed that PiB-C could efficiently label Aβ plaques and CAAs in AD mice.
机译：在本报告中，我们认为冠醚对淀粉状蛋白β（Aβ）的非共价修饰可以抑制其聚集。我们证明了PiB-C，一种共轭PiB和冠醚可以在体外显着减少聚集。此外，双光子成像显示PiB-C可以有效标记AD小鼠的Aβ斑块和CAA。

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  • 来源
    《Chemical Communications》 |2014年第99期|15792-15795|共4页
  • 作者

    Yanli Tian; Xueli Zhang; Yuyan Li; Timothy M. Shoup; Xin Teng; David R. Elmaleh; Anna Moore; Chongzhao Ran;

  • 作者单位

    Molecular Imaging Laboratory, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Building 75, Charlestown, Massachusetts 02129, USA,Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China;

    Molecular Imaging Laboratory, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Building 75, Charlestown, Massachusetts 02129, USA,Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China,School of Pharmacy, China Pharmaceutical University, Nanjing, China;

    Molecular Imaging Laboratory, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Building 75, Charlestown, Massachusetts 02129, USA,School of Pharmacy, China Pharmaceutical University, Nanjing, China;

    Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA;

    Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA;

    Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA;

    Molecular Imaging Laboratory, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Building 75, Charlestown, Massachusetts 02129, USA;

    Molecular Imaging Laboratory, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Building 75, Charlestown, Massachusetts 02129, USA;

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