Copper-mediated oxidative trifluoromethylthiolation of unactivated terminal alkenes

摘要

A general method to form a C(SP~3)-SCF_3 bond via copper-mediated oxidative trifluoromethylthiolation of unactivated alkenes with stable nucleophilic AgSCF_3 was developed. This protocol provides a direct and efficient access to a series of trifluoromethylthiolated allylic compounds with broad functional group tolerance.