A novel flavin derivative reveals the impact of glucose on oxidative stress in adipocytes

摘要

We present the synthesis and characterisation of naphthalimide-flavin redox sensor 1 (NpFRl), a novel flavin molecule that is almost non-fluorescent in reduced form, but oxidation gives rise to a 125-fold increase in fluorescence. Confocal microscopy experiments confirm that NpFRl is sensitive to redox changes within living cells.