Dual pH-triggered multistage drug delivery systems based on host-guest interaction-associated polymeric nanogels

摘要

The polymeric nanogels were constructed via host-guest interactions for dual pH-triggered multistage drug delivery, which showed tumor acidity-triggered nanogel reorganization into smaller nanoparticles for deep tissue penetration, high-efficiency cellular uptake, and intra-cellular endo-lysosomal pH-responsive drug release.