A coumarin-based fluorescent probe for recognition of Cu~(2+) and fast detection of histidine in hard-to-transfect cells by a sensing ensemble approach

摘要

A coumarin-based fluorescent chemosensor CAQA has been synthesized. It can selectively and sensitively recognize Cu~(2+) in aqueous acetonitrile solutions. Using the Cu-containing complex CAQA-Cu~(2+) as a sensing ensemble, the device demonstrates highly selective recognition of His/biothiols and was applied in fluorescence imaging of histidine in hard-to-transfect living cells.